The AKM is the improved version of the AK-47, featuring a number of refinements such as a stamped receiver (as opposed to the milled receiver of the original Type 2 and Type 3 AK-47), a slant compensator on the tip of the barrel (to reduce recoil), an improved gas tube (without vents), and use of lighter materials to reduce weight and simplify construction.
This work was supported through the Australian Institute of Nuclear Science and Engineering Ltd (AINSE) and the Australian Research Council (ARC) through the funding of the Discovery Grant DP160100545. This research was partially supported by the Australian Research Council Centre of Excellence in Future Low-Energy Electronics Technologies (Project number CE170100039) and funded by the Australian Government. N.V. and D.S. also acknowledge the support of the ARC Discovery Program. B.D. thanks the financial support of the Alexander von Humboldt Foundation and the Transregional Collaborative Research Center (SFB/TRR) SPIN+X. B.X. thanks the financial support of the Department of Energy, Office of Basic Energy Sciences, under Contract ER-46612 and acknowledge the Arkansas High Performance Computer Center at the University of Arkansas for access to their supercomputers. L.B. thanks DARPA Grant No. HR0011727183-D18AP00010 (TEE Program). B.X. also thanks support from Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions. L.B. thanks Michel Viret for discussions in 2013 about the possibility that the spin-current model of BFO can include first-nearest neighbors rather than second-nearest neighbors.
Nikonov I Ko Serial Number
An automatic pistol manufactured by a militia based in Shanxi Province, China. A copy of the C96 pistol, which was imported in large numbers into China in the early 20th century during a war against Japan. Capable of full-auto fire, but the recoil generated by its .45 caliber ammo, lack of tactical reload function (magazine must be empty), and small 10 round magazine mean that only experienced soldiers can make effective use of this capability. Its high impact rounds and rapid fire are enough to drop an enemy almost instantly. Was used by EVA during Operation Snake Eater in 1964. There are no modifications available for this weapon.
The PSS can be found in a number of locations. One can also be found in a ventilation shaft in the advent palace, just before you meet up with Rat Patrol 01. The player can see a crawl space on their right. It is fairly big and several items are in there including the PSS. It is also located in a fireplace inside the mansion during Act 2. The fireplace is located in the back room, first floor. The room has a long table in the middle. At the end of Act 2, another PSS can be found in the marketplace near a stall.
Despite the fact that it can potentially be the most powerful non-lethal weapon in Snake's arsenal, it is limited by its unique ammunition: sunlight. The Solar Gun runs on a battery that can only be recharged while exposed to direct sunlight. While in the first two acts sunlight is plentiful, the next three acts take place in environments where there is little to no sun, limiting the number of times he can use the gun. Fortunately, a full energy meter is provided every act, so with careful management, the Solar Gun can be used effectively. However, there is a bug in the game that allows you to recharge anywhere there is a wall. To execute this trick, any handgun, the Solar Gun, and a wall are required. First, fire a round out of the handgun. Press up against a wall and reload the handgun. Before the animation completes, switch to the solar gun. The solar gun will instantly be recharged, even in the absence of sunlight. This trick can also be used to quickly reload any other firearm with notably long reload time, such as the Tanegshima.
A small submachine gun developed as a self-defense weapon in Czechoslovakia during the Cold War. A rate reducer is installed inside the frame, keeping the firing rate down despite the light bolt weight allowing for greater control in full-auto mode. There are a number of ammo variations in Vz. series: this version uses 9mm Makarov rounds (9x18mm). Holds 20 rounds. Its standard laser sight enables easy on the fly aiming. There are no modifications available for this weapon. It can be obtained from Big Mama during Act 3. Also known as the "Skorpion."
Tanegashima is an old colloquial term for any number of smooth-bore, matchlock muzzle -loading firearms introduced to Japan in the 1500s. This weapon is based heavily on an old arquebus. It is a very cumbersome weapon to use, as it is a single-shot muzzle-loader, which requires Snake to stand in place while he reloads. Uses lead balls as ammo (rarely given as gifts by rebels in Act 2, this ammo cannot be found anywhere else in the game other than buying from Drebin). It is dreadfully inaccurate due to the lack of rifling (strangely, this weapon is classified as a rifle in MGS4 despite being a smooth-bore weapon). Tanegashima is utterly useless in most contexts of MGS4, however it has one special property. It has a 1 in 3 chance that it will generate a whirlwind, killing every enemy in its path, as well as spilling hundreds of items across the battlefield (it has to hit a soldier for this to happen as items in the soldier's inventory are cloned many times for this to happen). Unfortunately, the whirlwind effect can only happen outside and only in the first two three (will not happen in Act 4 even though it's very windy outside). There are no modifications available for this weapon. It can be obtained from Drebin for 1,000,000 DPs. An easier way is to buy it on a Wednesday or Sunday according to the PS3's system clock (the player can also change their PS3's date so they don't have to wait until it's actually Wednesday or Sunday) to get 20% off. The best way, however, is to purchase it in Act 5 for only half the price (the Sunday/Wednesday 20% discount does not apply during Act 5). With this weapon and the bandana it is possible to easily farm Drebin points, ammo and items thus giving you nearly infinite Drebin points.
This weapon will either cause affected individuals to more easily kill their foes, or it may cause greater exposure to enemy fire. Either way, it will not count towards Snake's own number of kills (unless he intervenes by using a different, lethal weapon).
We previously showed that JM-20, a novel 1,5-benzodiazepine fused to a dihydropyridine moiety, possessed an anxiolytic profile similar to diazepam and strong neuroprotective activity in different cell models relevant to cerebral ischemia. Here, we investigated whether JM-20 protects against ischemic neuronal damage in vitro and in vivo. The effects of JM-20 were evaluated on hippocampal slices subjected to oxygen and glucose deprivation (OGD). For in vivo studies, Wistar rats were subjected 90 min of middle cerebral artery occlusion (MCAo) and oral administration of JM-20 at 2, 4 and 8 mg/kg 1 h following reperfusion. Twenty-four hours after cerebral blood flow restoration, neurological deficits were scored, and the infarct volume, histopathological changes in cortex, number of hippocampal and striatal neurons, and glutamate/aspartate concentrations in the cerebrospinal fluid were measured. Susceptibility to brain mitochondrial swelling, membrane potential dissipation, H2O2 generation, cytochrome c release, Ca2+ accumulation, and morphological changes in the organelles were assessed 24 h post-ischemia. In vitro, JM-20 (1 and 10 μM) administered during reperfusion significantly reduced cell death in hippocampal slices subjected to OGD. In vivo, JM-20 treatment (4 and 8 mg/kg) significantly decreased neurological deficit scores, edema formation, total infarct volumes and histological alterations in different brain regions. JM-20 treatment also protected brain mitochondria from ischemic damage, most likely by preventing Ca2+ accumulation in organelles. Moreover, an 8-mg/kg JM-20 dose reduced glutamate and aspartate concentrations in cerebrospinal fluid and the deleterious effects of MCAo even when delivered 8 h after blood flow restoration. These results suggest that in rats, JM-20 is a robust neuroprotective agent against ischemia/reperfusion injury with a wide therapeutic window. Our findings support the further examination of potential clinical JM-20 use to treat
Stroke is frequently associated with severe neurological decline and mortality, and its incidence is expected to increase due to aging population. The only available pharmacological treatment for cerebral ischemia is thrombolysis, with narrow therapeutic windows. Efforts aimed to identify new therapeutics are crucial. In this study, we look into plausible molecular and cellular targets for JM-20, a new hybrid molecule, against ischemic stroke in vivo. Male Wistar rats were subjected to 90 min middle cerebral artery occlusion (MCAO) following 23 h of reperfusion. Animals treated with 8 mg/kg JM-20 (p.o., 1 h after reperfusion) showed minimal neurological impairment and lower GABA and IL-1β levels in CSF when compared to damaged rats that received vehicle. Immunocontent of pro-survival, phosphorylated Akt protein decreased in the cortex after 24 h as result of the ischemic insult, accompanied by decreased number of NeuN + cells in the peri-infarct cortex, cornu ammonis 1 (CA1) and dentate gyrus (DG) areas. Widespread reactive astrogliosis in both cortex and hippocampus (CA1, CA3, and DG areas) was observed 24 h post-ischemia. JM-20 prevented the activated Akt reduction, neuronal death, and astrocytes reactivity throughout the brain. Overall, the results reinforce the pharmacological potential of JM-20 as neuroprotective agent and provide important evidences about its molecular and cellular targets in this model of cerebral ischemia.
A study area near Ribeirao Preto in Sao Paulo state was selected, with predominance in sugar cane. Eight features were extracted from the 4 original bands of LANDSAT image, using low-pass and high-pass filtering to obtain spatial features. There were 5 training sites in order to acquire the necessary parameters. Two groups of four channels were selected from 12 channels using JM-distance and entropy criterions. The number of selected channels was defined by physical restrictions of the image analyzer and computacional costs. The evaluation was performed by extracting the confusion matrix for training and tests areas, with a maximum likelihood classifier, and by defining performance indexes based on those matrixes for each group of channels. Results show that in spatial features and supervised classification, the entropy criterion is better in the sense that allows a more accurate and generalized definition of class signature. On the other hand, JM-distance criterion strongly reduces the misclassification within training areas. 2ff7e9595c
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